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T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets

[ Vol. 4 , Issue. 2 ]


Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Bart-Jan Kroesen, Elisabeth Brouwer, Joost Kluiver, Annemieke M. H. Boots and Anke van den Berg   Pages 117 - 122 ( 6 )


T-cell activation affects microRNA (miRNA) expression in T-cell subsets. However, little is known about the kinetics of miRNA regulation and possible differences between CD4 and CD8 T cells. In this study we set out to analyze the kinetics of activation-induced expression regulation of twelve pre-selected miRNAs. The dynamics of the expression of these miRNAs was studied in sorted CD4 and CD8 CD45RO- T cells of healthy individuals stimulated with


Activation, antibodies, immune, microRNA, miRNA regulation, T cell.


Department of Pathology & Medical Biology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

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