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Article Details


microRNA Decay: Refining microRNA Regulatory Activity

[ Vol. 5 , Issue. 3 ]

Author(s):

Genevieve Pepin and Michael P. Gantier*   Pages 167 - 174 ( 8 )

Abstract:


MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.

Keywords:

Cleavage, degradation, exosome, microRNA, RNase, target mRNA.

Affiliation:

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168

Graphical Abstract:



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