Palmiro Poltronieri, Binlian Sun, Kai-Yao Huang, Tzu-Hao Chang and Tzong-Yi Lee* Pages 85 - 91 ( 7 )
Background: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers.
Objective: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs.
Methods: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets.
Results: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments.
Conclusion: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.
Human Papilloma Virus (HPV), microRNAs, oncogenesis, seed sequence complementarity, translation repression, immunity.
Department of Microbiology, Institute of Sciences of Food Productions, CNR-ISPA, Lecce, Department of Immunology, School of Medicine, Jianghan University, Wuhan, Department of Medical Research, Hsinchu Mackay Memorial Hospital, Hsinchu city, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Department of Computer Science & Engineering, Graduate Program in Biomedical Informatics, Yuan Ze University, Chung-Li