Submit Manuscript  

Article Details


Role of MicroRNA in the Diagnosis and Therapy of Hepatic Metastases from Colorectal Cancer

[ Vol. 7 , Issue. 3 ]

Author(s):

Angeliki Chorti, Petros Bangeas, Theodossis S. Papavramidis and Georgios Tsoulfas*   Pages 167 - 177 ( 11 )

Abstract:


Introduction: Colorectal cancer is one of the most common malignancies in both genders and liver metastasis appear in more than 50% of patients with colorectal cancer, worsening its morbidity and mortality rates. The existing methods for the diagnosis and prognosis of colorectal cancer seem to be insufficient to predict its aggressiveness, leading to poor outcomes for the patient.

Definition, biogenesis and function of miRNAs: MicroRNAs are small non-coding RNAs, which interact with mRNAs in a post-transcriptional stage, and have been found to be involved in pathogenesis of cancer and its metastases.

MiRNAs as a Diagnostic Tool for Colorectal Liver Metastasis: Their utility in diagnosis of colorectal liver metastasis gains ground through serum or tissue examination.

MiRNAs Related to Colorectal Liver Metastasis: Several miRNAs are related to colorectal cancer and its liver metastasis.

MiRNAs in Treatment and prognosis of Colorectal Liver Metastasis: Some of them have oncogenic and other tumor suppressive role in the development of colorectal liver metastasis, while many of them have been proved to be correlated with the overall survival and prognosis of patients with colorectal cancer. The aim of the present review is to give a detailed account of the different miRNAs that have been described as playing a role in hepatic metastases from colorectal cancer, emphasizing their diagnostic, prognostic and therapeutic implications.

Keywords:

Colorectal cancer prognosis, colorectal cancer, colorectal hepatic metastases, colorectal liver metastasis, microRNAs, therapeutic implications.

Affiliation:

1st Propaedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, 1st Propaedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, 1st Propaedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, 1st Department of Surgery, Papageorgiou Hospital , Aristotle University of Thessaloniki



Read Full-Text article