Submit Manuscript  

Article Details


MiRNAs: Biology, Biogenesis, their Web-based Tools, and Databases

[ Vol. 8 , Issue. 1 ]

Author(s):

Majid Tafrihi* and Elham Hasheminasab   Pages 4 - 27 ( 24 )

Abstract:


Introduction: MicroRNAs (miRNAs), which are evolutionarily conserved, and endogenous non-coding RNAs, participate in the post-transcriptional regulation of eukaryotic genes. The biogenesis of miRNAs occurs in the nucleus. Then, in the cytoplasm, they are assembled along with some proteins in a ribonucleoprotein complex called RISC. miRNA component of the RISC complex binds to the complementary sequence of mRNA target depending on the degree of complementarity, and leads to mRNA degradation and/or inhibition of protein synthesis. miRNAs have been found in eukaryotes and some viruses play a role in development, metabolism, cell proliferation, growth, differentiation, and death.

Objective: A large number of miRNAs and their targets were identified by different experimental techniques and computational approaches. The principal aim of this paper is to gather information about some miRNA databases and web-based tools for better and quicker access to relevant data.

Results: Accordingly, in this paper, we collected and introduced miRNA databases and some webbased tools that have been developed by various research groups. We have categorized them into different classes including databases for viral miRNAs, and plant miRNAs; miRNAs in human beings, mice and other vertebrates; miRNAs related to human diseases, and target prediction; and miRNA expression. Also, we have presented relevant statistical information about these databases.

Keywords:

Biogenesis, databases, miRNA, mRNA target, web-based tools, cytoplasm.

Affiliation:

Molecular & Cell Biology Research Lab. 2, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran, Molecular & Cell Biology Research Lab. 2, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran



Read Full-Text article