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The Role of microRNAs Identified in the Amniotic Fluid

[ Vol. 9 , Issue. 1 ]

Author(s):

Fasoulakis Zacharias*, Theodora Marianna , Tsirkas Ioannis, Tsirka Theodora, Kalagasidou Sofia, Inagamova Lola , Papamanolis Valentinos, Blontzos Nikolaos and Kontomanolis N. Emmanuel   Pages 8 - 16 ( 9 )

Abstract:


Aim: The study aimed to provide an overall view of current data considering the presence of microRNAs in amniotic fluid.

Methods: The available literature in MEDLINE, regarding the role of the amniotic fluid in pregnancy and fetal development, was searched for related articles including terms such as “microRNA”, “Amniotic fluid”, “Adverse outcome” and others.

Results: The amniotic fluid has an undoubtedly significant part in fetal nutrition, with a protecting and thermoregulatory role alongside. MicroRNAs have proven to be highly expressed during pregnancy in many body liquids including amniotic fluid and are transferred between cells loaded in exosomes, while they are also implicated in many processes during fetal development and could be potential biomarkers for early prediction of adverse outcomes.

Conclusion: Current knowledge reveals that amniotic fluid microRNAs participate in many developmental and physiological processes of pregnancy including proliferation of fibroblasts, fetal development, angiogenesis, cardioprotection, activation of signaling pathways, differentiation and cell motility, while the expression profile of specific microRNAs has a potential prognostic role in the prediction of Down syndrome, congenital hydronephrosis and kidney fibrosis.

Keywords:

Adverse outcomes, amniotic fluid, fetal development, microRNAs, pregnancy, exosomes.

Affiliation:

Department of Obstetrics and Gynecology, Democritus University of Thrace, Thrace, 1st Department of Obstetrics & Gynaecology, National and Kapodistrian University of Athens, Athens, Department of Obstetrics and Gynecology, Democritus University of Thrace, Thrace, Molecular Biology and Genetics, Democritus University of Thrace, Thrace, Department of Obstetrics and Gynecology, Bodosakio General Hospital of Ptolemaida, Department of Obstetrics and Gynecology, Democritus University of Thrace, Thrace, Department of Obstetrics and Gynecology, General Hospital of Korinthos, Korinthos, 1st Department of Obstetrics & Gynaecology, National and Kapodistrian University of Athens, Athens, Department of Obstetrics and Gynecology, Democritus University of Thrace, Thrace



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